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Schamel, Wolfgang & Reth, MichaelMax Planck Institute for Immunobiology, Freiburg, D
Expertise: biochemistry & modelling
Wolfgang Schamel's group uses modern biochemical approaches to understand the early steps of T cell activation. The scientific interest is centered around the molecular mechanism of how the TCR transmits information across the membrane. http://www.immunbio.mpg.de...schamel
Michael Reth's department is expert in the reconstitution of small signalling modules in Drosophila cells in a synthetic biology approach. In addition, the group works on BCR signalling and B cell development. http://www.immunbio.mpg.de...reth
Acuto, OresteSir Williams Dunn School of Pathology, Oxford (UK)
Expertise: biochemistry Molecular characterisation of TCR proximal signalling: interactome and phosphoproteome. We use quantitative mass spectrometry and infrared imaging to characterise the dynamics and stoichiometry of TCR signalling. http://users.path.ox.ac.uk/~oacuto/Home.html
Fugger, LarsWeatherall Institute of Molecular Medicine, Oxford (UK)
Expertise: Clinical investigation My group is focussed on the inter-phase between clinical and laboratory work, where the clinical and molecular neuroimmunology is particularly strong. In particlaur, we are interested in the autoimmune disease multiple sclerosis. http://www.clneuro.ox.ac.uk
Alarcon, BalbinoCentro Biologia Molecular, CSIC, Madrid (E)
Expertise: biochemistry Leading a group of 14 researchers dedicated to the study of the TCR in regard to organization in the membrane, mechanisms for signal transmission across the membrane and organization of a TCR signalosome. The technical expertise of the group is focused towards the use of biochemical techniques, confocal and electron microscopy and gene expression in bone marrow precursors. http://www.cbm.uam.es...
Baier, GottfriedDept. Medical Genetics, Medical University, Innsbruck (A)
Expertise: biochemistry The major research topic relates to the biochemical, molecular and functional analysis of signal transducing AGC-protein S/T kinases in order to understand the (patho)physiology of T lymphocytes. The underlying goal of the work is to understand their selective functions in signal transduction pathways in lymphocytes and to use this information to develop strategies to manipulate the immune response, either for immunosuppression in autoimmune diseases, graft rejection as well as the inflammatory response or for augmentation in cancer. To achieve these aims we apply modern biochemical, molecular, cellular and mouse genetic approaches. http://www.sfb021.at/baier/
Aebersold, Ruedi & Gstaiger, MatthiasInstitute for Molecular Systemsbiology, ETH-Zürich (CH)
Our research is focused on the development and the application of mass spectrometry (MS) based methods. Recent advances from the group include the development of chemical reagents for quantitative mass spectrometry, the development of a suite of software tools for the computational analysis of proteomics data and a quantitative MS based approach to the analysis of protein complexes. http://www.imsb.ethz.ch/researchgroup/rudolfa
A major focus in our lab is the systematic and quantitative analysis of intracellular information processing using mass spectrometry based approaches. We develop and apply new technologies to quantitatively resolve the spatio-temporal organization of proteins into complexes and signaling networks. http://www.imsb.ethz.ch/researchgroup/gstaigem
Höfer, ThomasDKFZ, BioQuant, Heidelberg (D)
Expertise: modelling Our group develops experimentally-based mathematical models for the dynamics of regulatory networks that govern proliferation and differentiation decisions in eukaryotic cells. We investigate processes at several levels of spatio-temporal organization, ranging from macromolecular machines in gene regulation to intra- and intercellular signaling networks, focusing on T lymphocytes. Cell-biological problems are addressed with a common modeling and simulation methodology, drawing on biochemical systems theory, nonlinear dynamics, stochastic processes, reaction-transport theory, and statistical concepts for model identification. http://www.dkfz.de/...
Lahesmaa, RiittaTurku Centre for Biotechnology, University of Turku (FIN)
Expertise: transcriptomics & modelling We are interested in elucidating the molecular mechanisms of immune mediated human diseases. The selective activation of functionally distinct subsets of human CD4+ lymphocytes plays an important role in the pathogenesis of allergy and inflammatory diseases. Cytokine network selectively regulates the development and differentiation of lymphocytes to Th1 or Th2 subsets with restricted profile of cytokine production. Our studies aim at identification of key factors and molecular mechanisms of lymphocyte differentiation and activation in relation to human disease. http://www.btk.fi/index.php?id=178
Lähdesmäki, HarriAalto University School of Science and Technology, Espoo (FIN)
We use computational techniques to model molecular regulatory mechanismsand their role in health and disease. We focus on analyzing andintegrating heterogeneous high-throughput data and developingstatistical modeling methods to understand transcriptional andpost-transcriptional regulatory mechanisms, protein signaling pathways,and effects of mutations on these mechanisms.
Malissen, Marie & Malissen, BernardCentre d'Immunologie INSERM-CNRS, Marseille-Luminy (F)
Expertise: animal models Our group has extensive experience and a record of contributions to the following fields:
(1) genetic analysis of the components of the T cell receptor transduction cassette;
(2) molecular basis of T cell development and T cell physiology;
(3) identification of genes associated with T cell and dendritic cell functions.
Using knock-in/knock-out approaches this group has systematically dissected the proximal elements of the TCR transduction cassette (CD3, Lck, ZAP-70, LAT). Bernard Malissen also supervises the IBISA Platform for Immunophenomics that comprises a "fast-track assembly line" to engineer innovative knock-in mouse model devoted to the analysis of the complexity of the immune system under normal and pathological conditions.
Palmer, EdDepartment of Biomedicine, University Hospital Basel (CH)
Expertise: T-cell biology The Laboratory has an extensive experience with OT-I T-cells, OT-I transgenic mice and ligands for this TCR. It has expertise in the TCR signals leading to T-cell tolerance, T-cell activation, AICD, and the development of memory T-cells. The group has a great deal of knowledge regarding the effect of ligand affinity on TCR signalling and has described how the Ras signalling components are compartmentalised in thymocytes during thymic selection. http://www.unibas.ch
Schraven, Burkhart & Lindquist, JonathanInstitute of Molec & Clinical Immunology, University of Magdeburg (D)
Expertise: biochemistry & modelling Our group has been actively involved in establishing a qualitative model describing the signalling network organised by the TCR/CD3 complex, the co-receptors CD4/CD8 and the costimulatory molecule CD28. Additionally, we are experts in the field of T-cell activation, particularly in the analysis of transmembrane adaptors, proteins which serve as scaffolds for organising the formation of signalling complexes at the membrane. http://www.med.uni-magdeburg.de/fme/institute/iim/
Antonella, ViolaFondazione Humanitas per la Ricerca, Milano (I)
Expertise: Imaging My group studies signals modulating the immune response in physiopathological conditions. We try to understand how to help lymphocytes to fight cancer or viruses on the one side, and, on the other, how to block improper lymphocyte activation and thus autoimmune diseases. In particular my group works on Cell migration, T cell priming and T cell effector functions. http://www.vimm.it, http://www.humanitas.it
Villoslada, PabloCenter for Neuroimmunology
IDIBAPS – Hospital Clinic of Barcelona
Expertise: clinical investigation Pablo Villoslada's research is aimed to understand the pathogenesis of Multiple Sclerosis and developing new therapies and diagnostic tools for such disease. In order to achieve such goals, the main approach for our team is by applying systems biology for the study of signaling pathways in the immune system such as type I interferon or T cell receptor. We aim to apply such discoveries to the identification of new biomarkers and therapeutics targets for the disease.
http://www.reem.es/idibaps/ , http://www.idibaps.org/research/709/neuroimmunology
Markus FeuererDKFZ, Heidelberg (D)
Expertise: animal models
The group of Markus Feuerer uses the NOD mouse model ofautoimmune diabetes, in order to understand the mechanismsthat contribute to the development of this disease.
Rao, AnjanaHarvard Medical School & Immune Disease Institute, Boston (USA)
Rao, KanuryInternat. Centre for Genetic Engineering & Biotechnology, Delhi (IND)
Mathis, Diane & Benoist, ChristopheJoslin Diabetes Center, Harvard Medical School, Boston (USA)
Suchanek, MiloslavEXBIO Praha, Antibody-producing Company, Vestec (CZ)
Expertise: antibody development EXBIO Praha - Dedicated to Superior Cytometry Reagents We are the progressive company focused on the design, development, manufacture and sales of high quality monoclonal antibodies for research and clinical diagnosis. We strive to provide the complex offer of services and products for the field of analytical cytometry, including analysis of cell signaling events. http://www.exbio.cz
Rival, SandrineNovamen, Research Promotion and Managing Company, Lyon (F)
Expertise: Project management, use, exploitation ACIES advises and assists players in Research and Innovation in the promotion of their projects at economic, scientific and society level. On the basis of an innovative management system and in-depth knowledge of the elements at stake and the major players in Research, ACIES' skills are deployed via two activities: Financing of Research and Innovation Management of research networks and projects ACIES is an example of European excellence in the management of complex and large-scale European research projects. This SME will apply its leadership and quality management systems to the field of research management, providing proven and specialised procedures to the members of the SYBILLA consortium. ACIES will also coordinate the IPR Committee and will thus ensure an efficient and relevant use and exploitation of the project results. http://www.acies.fr