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SYBILLA (Systems biology of T-cell activation in health and disease)

SYBILLA, systems biology of T-cell activation in health and disease, is a European Union-funded large integrated project in framework program 7 (FP7). It is funded for 5.5 years with 11.1 mio Euro and started in April 2008. It has 14 scientific and 3 industrial partners from 11 countries, lead by Dr. Wolfgang Schamel, University of Freiburg, Freiburg, Germany, as the scientific coordinator.

The goal of SYBILLA is to understand the intracellular signalling network of T cells that determines T cell fate.

UPCOMING:
The standardized protocols developed and used in SYBILLA are now made availabel to the public and can be downloaded under the "protocol" section.

Although funding by the EU terminated in September 2013, SYBILLA members decided on their last meeting to continue with their intense collaborations using other resources. 
Thus, we can announce that
the next SYBILLA meeting takes place on the 1st and 2nd October 2014 in Madrid, 
organized by Balbino Alarcon !!!
  




Download the Flyer.




"Every part is reciprocally both end and means. In such a product nothing is in vain, without an end, or to be ascribed to a blind mechanism of nature."
Immanuel Kant


 

Research

Background
signaltransduct
Saez-Rodriguez et al. 2007 PLoS Comput.Biol.

The immune system has to discriminate pathogens (e.g. bacteria or viruses and cancerous cells) from healthy cells within our body. Foreign cells should be attacked and eliminated, whereas self-tissues should not be harmed. The main cell type involved in this decision is the T-cell.

T-cell activation is a complex process relying on multiple layers of tightly controlled intracellular signaling molecules, which form an intricate and dynamic network. Defects in this network can cause autoimmune responses that destroy normal body cells: Horror autotoxicus. This term was coined by the bacteriologist and immunologist Paul Ehrlich (1854-1915) to describe the body's immunological self-destruction in severe disorders such as multiple sclerosis. In order to understand and predict the behaviour of this network it is therefore crucial to study it as a complete system and not only its isolated parts.

Scientific concept
carlos_formel

Through a multidisciplinary effort SYBILLA aims to understand at systems level, how T-cells discriminate foreign- from self-peptides by activating quantitatively distinct signaling pathways. Data obtained in mouse models are extended to human T cells and to a mouse model of multiple sclerosis.
SYBILLA develops new analytical and mathematical tools to generate and integrate high-density quantitative data describing T-cell activation. Proteomics, transcriptomics, imaging and biochemical techniques will be applied to obtain holistic maps of the T-cell signaling network and to achieve a quantitative and dynamic understanding of signaling networks and their regulation in response to different signal inputs.
Building upon already existing schemes of the network connectivity, constant iteration between experiment and mathematical modelling will be used to develop robust and predictive models that describe the functioning of the T-cell signaling network. SYBILLA will allow the identification of new drug targets and the discovery of new biomarkers to refine prognosis of autoimmune diseases.

Publications
Proteomics


A list of publications of the SYBILLA consortium can be seen in these tables here. Or you can downloaded them:



List of scientific publications of the SYBILLA consortium for 2012

Title

Peer-reviewed journal

Year

Relevant pages

Pubmed

Partners involved

T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.

JBC

2011

7535-47

PMID: 21189249

Acuto O,

UOXFa

Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks.

PLoS ONE

2011

e22928

PMID: 21829558

Höfer T, DKFZ

Schamel W, MPI-IB

Integrating signals from the T-cell receptor and the interleukin-2 receptor

PLoS Comput Biol

2011

e1002121

PMID: 21829342

Schraven B, Lindquist J, UNIMAG

Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes.

Immunity

2011

375-87

PMID: 21903423

 

Alarcon B, CSIC, Schamel W, MPI-IB

The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: effects of acute relapse and immunomodulatory treatment

Mult Scler

2011

851-866

PMID: 21561957

 

Lindquist J, UNIMAG

Molecular T cell biology?-?basic and translational challenges in the twenty-first century.

Front Immunol

2011

ePub

PMID: 22566794

 

Acuto O,

UOXFa

LAT signaling pathology: an "autoimmune" condition without T cell self-reactivity.

Trends Immunol

2010

253-259

PMID: 20542732

 

Malissen B, CNRS

Signaling in thymic selection.

Curr Opin Immunol

2011

207-212

PMID: 21242076

 

Palmer E, UNIBAS

Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation.

Mol Cell Proteomics

2010

1937-1953

PMID: 20467038

 

Lahesmaa R, UTU

SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation.

Blood

2010

1443-1453

PMID: 20522714

 

Lahesmaa R, UTU

Structural characterization of the TCR complex by electron microscopy.

 

Int Immunol

2010

897-903

PMID: 21059766

 

Alarcon B, CSIC, Schamel W, MPI-IB

Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.

Immunity

2010

852-862

PMID: 20620947

 

Lahesmaa R, UTU

A new vampire saga: the molecular mechanism of T cell trogocytosis.

Immunity

2011

151-153

PMID: 21867922

 

Schamel W, MPI-IB

Coronin 1A is an essential regulator of the TGFß receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells.

J Autoimmun

2011

198-208

PMID: 21700422

 

Baier G, MUI

Synthetic immune signaling

Curr Opin Biotech

2012

1-5

PMID: 22326912

 

Schamel W,

Reth M, MPI-IB

TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.

Front Immunol

2012

ePub

PMID: 22582078

 

Alarcon B, CSIC

T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.

Immunity

2011

208-222

PMID: 21820331

 

Alarcon B, CSIC

Identification of early gene expression changes during human Th17 cell differentiation.

Blood

2012

ePub

PMID: 22544700

 

Lahesmaa R, UTU

A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection.

J Recept Signal Transduct Res

2012

430-443

PMID: 20945976

 

Palmer E, UNIBAS

Meeting report signal transduction meets systems biology.

Cell Commun Signal

2012

ePub

PMID: 22546078

 

Lindquist J, UNIMAG, Schamel W,

MPI-IB

Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.

PLoS One

2011

e23978

PMID: 21915273

 

Lindquist J,

Schraven B, UNIMAG

The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: effects of acute relapse and immunomodulatory treatment.

Mult Scler

2011

851-866

PMID: 21561957

 

Lindquist J,

UNIMAG

Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12.

PLoS One

2011

e22482

PMID: 21853036

 

Viola A,

FHR

The critical role of agrin in the hematopoietic stem cell niche.

Blood

2011

2733-2742

PMID: 21653324

 

Viola A,

FHR

Agrin is required for survival and function of monocytic cells.

Blood

2012

ePub

PMID: 22517892

 

Viola A,

FHR




List of scientific publications of the SYBILLA consortium for 2009 and 2010

Title

Journal

Year

Pages

Pubmed number

SYBILLA Partners

Quantitative interaction proteomics using mass spectrometry.

Nat Methods

2009

203-205

PMID: 19198594

Aebersold R, Gstaiger M. ETHZ

STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells.

J Immunol.

2009

2680-2689

PMID: 19234162

Malissen B Malissen M CNRS

T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides.

Immunity

2009

348-357

PMID: 19303388

Fugger L. UOXF

PKC inhibitors: potential in T cell-dependent immune diseases.

Curr Opin Cell Biol

2009

262-267

PMID: 19195860

Baier G MUI

Loss of the LAT adaptor converts antigen­ responsive T cells into pathogenic effectors that function independently of the T cell receptor.

Immunity

2009

197-208

PMID: 19682930

Malissen B, CNRS

Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes

Sem Immunopath.

2010

117-125

PMID: 20107804

Malissen B, CNRS

Signaling amplification at the immunological synapse.

Current Topics Microbiol Immunol

2010

109-122

PMID: 19960311

Viola A, FHR

Tunable chemokine production by antigen presenting dendritic cells in response to changes in regulatory T cell frequency in mouse reactive lymph nodes.

PLOSone

2009

4:e7696

PMID: 19893746

Viola A, FHR

A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2

Blood

2010

1637-1647

PMID: 20147700

Viola A, FHR

Constitutively active Lck in T cell drives antigen receptor signal transduction

Immunity

2010

766-777

PMID: 20541955

Viola A, FHR,

Acuto O, UOXFa, Fugger L. UOXFb,

Höfer T, DKFZ

PKC-theta Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination & Degradation

Science Signaling

2009

ra30

PMID: 19549985

Baier G. MUI

The potent protein kinase C selective inhibitor AEB071 (Sotrastaurin)represents a new class of immunosuppressive agents affecting early T cell activation

J Pharmacol Exp Ther.

2009

792-801

PMID: 19491325

Baier G. MUI

PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.

Mol Immunol

2009

2071-2079

PMID: 19356803

Baier G. MUI

(PKC inhibitors: potential in T cell-dependent immune diseases

Curr Opin Cell Biol.

2009

262-267

PMID: 19195860

Baier G, MUI

NFAT pulls the strings during CD4+ T helper cell effector functions.

Blood

2010

2989-2997

PMID: 20103781

Baier G. MUI

SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation

Blood

2010

1443-1453

PMID: 20522714

Lahesmaa R, UTU

Quantitative Proteomics Analysis of the Nuclear Fraction of Human CD4+ Cells in the Early Phases of IL-4 Induced Th2 Differentiation

Molec Cell Proteomics

2010

1937-1953

PMID: 20467038

Lahesmaa R, UTU

Analysis of novel phospho-ITAM specific antibodies in a S2 reconstitution system for TCR-CD3 signalling

Imm Lett

2010

43-50

PMID: 20005895

Schamel W, MPI-IB Suchanek M, EXBIO

Stoichiometry and intracellular fate of TRIM­containing TCR complexes

Cell Commun Signal

2010

8:5

PMID: 20298603

Schamel W, MPI-IB Schraven B, UNIMAG

Detection of phosphorylated T and B cell antigen receptor species by Phos-tag SDS-and Blue Native-PAGE

Imm Lett

2010

51-56

PMID: 20005898

Schamel W, MPI-IB

Das Imunsystem besser verstehen lernen

systembiologie.de

2010

51-55

 

Höfer T, DKFZ Lindquist J, Schraven B, UNIMAG

Schamel W, MPI-IB

 

 


  

Members

kick-off meeting
kick-off meeting, Heidelberg, 3rd May 2008

Involved in the SYBILLA project are:

Partners

carlos_formel

Academic partners

Schamel, Wolfgang & Reth, Michael

Max Planck Institute for Immunobiology, Freiburg, D
Expertise: biochemistry & modelling

Schamel
Wolfgang Schamel's group uses modern biochemical approaches to understand the early steps of T cell activation. The scientific interest is centered around the molecular mechanism of how the TCR transmits information across the membrane. http://www.immunbio.mpg.de...schamel
Reth



Michael Reth's department is expert in the reconstitution of small signalling modules in Drosophila cells in a synthetic biology approach. In addition, the group works on BCR signalling and B cell development. http://www.immunbio.mpg.de...reth

Acuto, Oreste

Sir Williams Dunn School of Pathology, Oxford (UK)
Expertise: biochemistry
Acuto
Molecular characterisation of TCR proximal signalling: interactome and phosphoproteome. We use quantitative mass spectrometry and infrared imaging to characterise the dynamics and stoichiometry of TCR signalling. http://users.path.ox.ac.uk/~oacuto/Home.html

Fugger, Lars

Weatherall Institute of Molecular Medicine, Oxford (UK)
Expertise: Clinical investigation
Fugger
My group is focussed on the inter-phase between clinical and laboratory work, where the clinical and molecular neuroimmunology is particularly strong. In particlaur, we are interested in the autoimmune disease multiple sclerosis. http://www.clneuro.ox.ac.uk

Alarcon, Balbino

Centro Biologia Molecular, CSIC, Madrid (E)
Expertise: biochemistry
Alarcon
Leading a group of 14 researchers dedicated to the study of the TCR in regard to organization in the membrane, mechanisms for signal transmission across the membrane and organization of a TCR signalosome. The technical expertise of the group is focused towards the use of biochemical techniques, confocal and electron microscopy and gene expression in bone marrow precursors. http://www.cbm.uam.es...

Baier, Gottfried

Dept. Medical Genetics, Medical University, Innsbruck (A)
Expertise: biochemistry
Baier
The major research topic relates to the biochemical, molecular and functional analysis of signal transducing AGC-protein S/T kinases in order to understand the (patho)physiology of T lymphocytes. The underlying goal of the work is to understand their selective functions in signal transduction pathways in lymphocytes and to use this information to develop strategies to manipulate the immune response, either for immunosuppression in autoimmune diseases, graft rejection as well as the inflammatory response or for augmentation in cancer. To achieve these aims we apply modern biochemical, molecular, cellular and mouse genetic approaches. http://www.sfb021.at/baier/

Aebersold, Ruedi & Gstaiger, Matthias

Institute for Molecular Systemsbiology, ETH-Zürich (CH)
Expertise: proteomics
Aebersold

Our research is focused on the development and the application of mass spectrometry (MS) based methods. Recent advances from the group include the development of chemical reagents for quantitative mass spectrometry, the development of a suite of software tools for the computational analysis of proteomics data and a quantitative MS based approach to the analysis of protein complexes.   http://www.imsb.ethz.ch/researchgroup/rudolfa



A major focus in our lab is the systematic and quantitative analysis of intracellular information processing using mass spectrometry based approaches. We develop and apply new technologies to quantitatively resolve the spatio-temporal organization of proteins into complexes and signaling networks.
Gstaiger
http://www.imsb.ethz.ch/researchgroup/gstaigem 

Höfer, Thomas

DKFZ, BioQuant, Heidelberg (D)
Expertise: modelling
Höfer
Our group develops experimentally-based mathematical models for the dynamics of regulatory networks that govern proliferation and differentiation decisions in eukaryotic cells. We investigate processes at several levels of spatio-temporal organization, ranging from macromolecular machines in gene regulation to intra- and intercellular signaling networks, focusing on T lymphocytes. Cell-biological problems are addressed with a common modeling and simulation methodology, drawing on biochemical systems theory, nonlinear dynamics, stochastic processes, reaction-transport theory, and statistical concepts for model identification. http://www.dkfz.de/...

Lahesmaa, Riitta

Turku Centre for Biotechnology, University of Turku (FIN)
Expertise: transcriptomics & modelling
Lahesmaa
We are interested in elucidating the molecular mechanisms of immune mediated human diseases. The selective activation of functionally distinct subsets of human CD4+ lymphocytes plays an important role in the pathogenesis of allergy and inflammatory diseases. Cytokine network selectively regulates the development and differentiation of lymphocytes to Th1 or Th2 subsets with restricted profile of cytokine production. Our studies aim at identification of key factors and molecular mechanisms of lymphocyte differentiation and activation in relation to human disease. http://www.btk.fi/index.php?id=178 

Lähdesmäki, Harri

Aalto University School of Science and Technology, Espoo (FIN) 
Laehdesmaeki
We use computational techniques to model molecular regulatory mechanismsand their role in health and disease. We focus on analyzing andintegrating heterogeneous high-throughput data and developingstatistical modeling methods to understand transcriptional andpost-transcriptional regulatory mechanisms, protein signaling pathways,and effects of mutations on these mechanisms.
http://users.ics.tkk.fi/harrila/

Malissen, Marie & Malissen, Bernard

Centre d'Immunologie INSERM-CNRS, Marseille-Luminy (F)
Expertise: animal models
Malissen
Our group has extensive experience and a record of contributions to the following fields:
(1) genetic analysis of the components of the T cell receptor transduction cassette;
(2) molecular basis of T cell development and T cell physiology;
(3) identification of genes associated with T cell and dendritic cell functions.
Using knock-in/knock-out approaches this group has systematically dissected the proximal elements of the TCR transduction cassette (CD3, Lck, ZAP-70, LAT). Bernard Malissen also supervises the IBISA Platform for Immunophenomics that comprises a "fast-track assembly line" to engineer innovative knock-in mouse model devoted to the analysis of the complexity of the immune system under normal and pathological conditions.

Palmer, Ed

Department of Biomedicine, University Hospital Basel (CH)
Expertise: T-cell biology
Palmer
The Laboratory has an extensive experience with OT-I T-cells, OT-I transgenic mice and ligands for this TCR. It has expertise in the TCR signals leading to T-cell tolerance, T-cell activation, AICD, and the development of memory T-cells. The group has a great deal of knowledge regarding the effect of ligand affinity on TCR signalling and has described how the Ras signalling components are compartmentalised in thymocytes during thymic selection. http://www.unibas.ch

Schraven, Burkhart & Lindquist, Jonathan

Institute of Molec & Clinical Immunology, University of Magdeburg (D)
Expertise: biochemistry & modelling
SchravenLindquist
Our group has been actively involved in establishing a qualitative model describing the signalling network organised by the TCR/CD3 complex, the co-receptors CD4/CD8 and the costimulatory molecule CD28. Additionally, we are experts in the field of T-cell activation, particularly in the analysis of transmembrane adaptors, proteins which serve as scaffolds for organising the formation of signalling complexes at the membrane. http://www.med.uni-magdeburg.de/fme/institute/iim/ 

Antonella, Viola

Fondazione Humanitas per la Ricerca, Milano (I)
Expertise: Imaging
Antonella
My group studies signals modulating the immune response in physiopathological conditions. We try to understand how to help lymphocytes to fight cancer or viruses on the one side, and, on the other, how to block improper lymphocyte activation and thus autoimmune diseases. In particular my group works on Cell migration, T cell priming and T cell effector functions. http://www.vimm.it, http://www.humanitas.it 

Villoslada, Pablo

Center for Neuroimmunology
IDIBAPS – Hospital Clinic of Barcelona
Villoslada
Pablo Villoslada's research is aimed to understand the pathogenesis of Multiple Sclerosis and developing new therapies and diagnostic tools for such disease. In order to achieve such goals, the main approach for our team is by applying systems biology for the study of signaling pathways in the immune system such as type I interferon or T cell receptor. We aim to apply such discoveries to the identification of new biomarkers and therapeutics targets for the disease.
http://www.reem.es/idibaps/ , http://www.idibaps.org/research/709/neuroimmunology 

Arno Hänninen

Medical Microbiology and Immunology, University of Turku
Haenninen
Our group investigates the immune pathogenesis of type 1 diabetes in the nonobese diabetic (NOD) mouse model. We are particularly interested inactivation of diabetogenic T lymphocytes in these mice, and in the following phases of T-cell activation in response to encounter withautoantigen. The BDC2.5 T cells provide an interesting model to study these phenomena both in vivo and in vitro, and are part of our currentresearch focus in addition to environmental, mostly gut-associated factors in diabetes pathogenesis in NOD mice. http://www.med.utu.fi/mikrobiologia/tutkimus/

Rao, Anjana

Harvard Medical School & Immune Disease Institute, Boston (USA)

Rao, Kanury

Internat. Centre for Genetic Engineering & Biotechnology, Delhi (IND)

Mathis, Diane & Benoist, Christophe

Joslin Diabetes Center, Harvard Medical School, Boston (USA)

Industrial partners

Suchanek, Miloslav

EXBIO Praha, Antibody-producing Company, Vestec (CZ)
Expertise: antibody development
Suchanek
EXBIO Praha - Dedicated to Superior Cytometry Reagents We are the progressive company focused on the design, development, manufacture and sales of high quality monoclonal antibodies for research and clinical diagnosis. We strive to provide the complex offer of services and products for the field of analytical cytometry, including analysis of cell signaling events. http://www.exbio.cz

Rival, Sandrine

Novamen, Research Promotion and Managing Company, Lyon (F)
Expertise: Project management, use, exploitation
Carbonnelle
ACIES advises and assists players in Research and Innovation in the promotion of their projects at economic, scientific and society level. On the basis of an innovative management system and in-depth knowledge of the elements at stake and the major players in Research, ACIES' skills are deployed via two activities: Financing of Research and Innovation Management of research networks and projects ACIES is an example of European excellence in the management of complex and large-scale European research projects. This SME will apply its leadership and quality management systems to the field of research management, providing proven and specialised procedures to the members of the SYBILLA consortium. ACIES will also coordinate the IPR Committee and will thus ensure an efficient and relevant use and exploitation of the project results. http://www.acies.fr

Advisors

Scientific advisory board (SAB)
The SAB is composed of external experts recognised for their expertise in the field of the project:
Project ethics committee (PEC)
The role of the PEC will be to review the ethical aspects of the research activities carried out in the project.
Industrial liaison council (ILC)
The ILC is composed of large industrialists with strong interests in the activities conducted within the project.

Supporters

The Signal Transduction Society

STS
The Signal Transduction Society (STS) is devoted to scientific exchange between investigators concerned with cellular signal transduction. Therefore, it supports SYBILLA in the dissemination of research as well as in the organization of meetings. http://www.sigtrans.de/

The Immunological Genome Project

ImmGen
The Immunological Genome Project (ImmGen) generates a complete microarray dissection of gene expression in the mouse immune system. Therefore, it is complementary to SYBILLA. Joint activities are planned. http://www.immgen.org/index_content.html

The Immune Response Consortium

The Immune Response Consortium (IRC) is a US-based consortium that models biological networks. 
http://web.mit.edu/irc/





Resources

Here you can download PDF and powerpoint documents that present SYBILLA as well as press releases related to SYBILLA.

PDF documents

Powerpoint shows

Press releases

Old Flyers

 

Events

Teamwork
SYBILLA is also devoted to teaching activities.

These include
(i) workshops within the consortium in order to teach standardized, robust techniques and
(ii) conferences for a wide scientific audienc and
(iii) the SYBILLA meetings, where ongoing projects are presented.

Workshops

Bioinformatics

Bioinformatics, 22nd - 24th September 2008, Espoo, Finland
Partner MEDICEL has successfully performed a workshop on bio-informatics, including data integration into MEDICEL data warehouse, integration of isolated data banks with various biological information such as DNA, mRNA, protein. 14 scientists participated and the workshop materials are available on the MEDICEL website.

Management, 9th - 10th February  2009, Lyon, France
Partner ACIES offered a focussed training of management activities for large consortia, reporting FP7 projects to the EU and ethics in conducting research projects. 12 finacial and administrative officers participated.

Proteomics

Proteomics, 23rd - 24th March 2009, Zürich, Switzerland
Partner ETHZ will provide a training session on quantitative proteomics using mass spectroscopy.


Standardized Biotechniques, 25th - 27th March 2009, Freiburg, Germany
Partner MPI-IB will provide a compulsory workshop for SYBILLA partners that teaches the use of standardised cell biology and biochemistry protocols. The standardized protocols will be made availbale through the SYBILLA website.


Systems Biology I, 10th - 12th June 2009, Heidelberg, Germany
Partner DKFZ plans to perform a workshop for training in (1) methods of mathematical modelling & data analysis aimed at experimentalists, (2) immunology and cell biology aimed at theoreticians, (3) research workshop on interaction of experiment and theory.


Transcriptomics, March  2009, Freiburg, Germany
Partner UTU will offered a small workshop on transcriptomics in the analysis of human T-cell differentiation and function.


Systems Biology II, August 2010, Magdeburg, Germany
Partner UNIMAG performed a training in methods of mathematical modelling and data analysis aimed at experimentalists, immunology and cell biology aimed at theoreticians and research workshop on interaction of experiment and theory.


Drosophila S2 Cell Expression System, March 2011, Lyon, France
Partner MPI-IB performed theoretical and methods sessions in the use of the drosophila S2 cell expression system, to reconsitute small signalling modules. The focus was on early T and  B cell signalling.


IPR/Technology transfer, March 2011, Lyon, France
Partner Novamen has invited two experts to talk about intellectual properties and how to expoit them.





SYBILLA organizes biannual consortium meetings as well as international conferences. Both are listed here.

kick-off meeting
Group picture at the kick-off meeting in Heidelberg 2008.


Archive: | 2008-2009 | 2010-2011 | 2012-2013 |


Scientific Conferences

Eight scientific conferences were organized by SYBILLA:

"T-cell signalling and technologies"
Prague, Czech Republic, 25th and 26th March 2010.

"Molecular and systems immunology to understand
basic mechanisms of immune mediated diseases"
Turku, Finland, 2nd and 3rd August 2010

"Signal Transduction: Receptors, Mediators and Genes"
co-organized with the Signal Transduction Society (STS)
Weimar, Germany, 7th to 9th November 2011

"Immunodeficiency and beyond ..."
co-organized with the Centre for Chronic Immunodeficiency (CCI) and the CRC620
Freiburg, Germany, 29th to 31st March 2012

"5th gamma-delta T-cell conference"
co-organized with the German Research Council
Freiburg, Germany, 31st May to 2nd June 2012

"Signaling and Gene Expression in the Immune System"
co-organized with SyMMyS
Turku, Finland, 13th and 14th August 2012

"Signal Transduction: Receptors, Mediators and Genes"
co-organized with the Signal Transduction Society (STS)
Weimar, Germany, 5th to 7th November 2012

"Systems Biology of T-cell activation"
The last SYBILLA meeting with the guest speakers Michael Dustin (USA), Anton van der Merwe (U.K.) and Omer Dushek (U.K.).
Oxford, U.K., 15th to 18th September 2013



2008-2009

SYBILLA Events 2008-2009

Strategical meeting, M6
The Executive Management Committee and Governing Board meetings took place in Madrid, Spain, on the 22nd and 23rd October 2008. The organization was done by Balbino Alarcon (CSIC), Caroline Carbonelle (ACIES) and Wolfgang Schamel (MPI-IB).

Strategical meeting, M12
The Executive Management Committee and Governing Board meetings took place in Sardinia, Italy, from the 23rd to 25th April 2009. The organization was done by Bernard Malissen (CNRS), Caroline Carbonelle (ACIES) and Wolfgang Schamel (MPI-IB).

Strategical meeting, M18
The Executive Management Committee and Governing Board meetings took place in Milano, Italy, from the 21st to 22nd October 2009. The organization was done by Antonella Viola (FHR), Sandrine Rival (ACIES) and Wolfgang Schamel (MPI-IB).
On the 20th October we had a pure "science day" with the following invited collaborators:
Carmen Molina Paris (Leeds, UK), Utz-Uwe Haus (Magdeburg, Germany), Harri Lähdesmäki (Turku, Finland).






2010-2011

SYBILLA Events 2010-2011

Strategical meeting, M24
The Executive Management Committee and Governing Board meetings took place in Prague, Czech Republic, on the 27th October 2010. The organization was done by Miloslav Suchanek (EXBIO) and Wolfgang Schamel (MPI-IB).
This meeting followed an international scientific conference on T-cell signalling and technologies, which took place on the 25th and 26th March 2010.

Strategical meeting, M30
The Executive Management Committee and Governing Board meetings took place in Innsbruck, Austria, on the 27th September 2010. The organization was done by Gottfried Baier (MUI), Sandrine Rival (NOVAMEN) and Wolfgang Schamel (MPI-IB).

Mid-term review
The mid-term review has taken place in Innsbruck, Austria, on the 28th and 29th September 2010. Fortunately, the opinion of the reviewers on the SYBILLA project was very positive.

Strategical meeting, M36
The Executive Management Committee and Governing Board meetings took place in Lyon, France, on the 23rd to 25th March 2011. The organization was done by Sandrine Rival (NOVAMEN) and Wolfgang Schamel (MPI-IB).

Strategical meeting, M42
The Executive Management Committee and Governing Board meetings took place in Weimar, Germany, on the 6th and 7th November 2011. The organization was done by Jon Lindquist (UNIMAG), Sandrine Rival (NOVAMEN) and Wolfgang Schamel (MPI-IB).

International conference "Signal Transduction: Receptors, Mediators and Genes"
The M42 meeting was followed by an international conference that SYBILLA and the Signal Transduction Society (STS) organized: the 15th international conference “Signal transduction – receptors, mediators and genes” which was held in Weimar, Germany, from November 07-09, 2011. This annual conference attracted 300 participants and 20 industrial exhibitors. The main focus was on Immune Cell Signaling with a special emphasis on systems biology of lymphocyte activation.
A number of outstanding scientists participated, including Tony Hunter (USA) (who was honored for his outstanding achievements in the field with the STS/CCS Honorary Medal 2011), Rudi Hendriks (Netherlands), Sankar Ghosh (USA), Ed Palmer (Basel), Oreste Acuto (UK), Balbino Alarcon (Spain), Wolfgang Schamel (Germany), Riitta Lahesmaa (Finland), Valeria Poli (Italy), Oliver Fakler (Germany) and Peter ten Dijke (Netherlands).


More information can be found on: http://www.sigtrans.de/start.shtml.

A summary of this outstanding event is found at:
http://www.biosignaling.com/content/10/1/11/abstract



2012-2013

SYBILLA Events 2012-2013

Strategical meeting, M48
The Executive Management Committee and Governing Board meetings took place in Freiburg, Germany, on the 28th and 29th March 2012. On the 28th we had the famous "science day" and on the 27th a "modeler's day".

International conference "Immunodeficiency and beyond"
The M48 meeting is followed by an international conference that the Centre for Chronic Immunodeficiency (CCI), the CRC 620 and SYBILLA co-organize entitled "Immunodeficiency and beyond". It took place from 29th March to 31st March 2012.
More information can be found on:
http://www.uniklinik-freiburg.de/cci/live/events/Symposium-2012_en.html

International conference "Fifth International Gamma-Delta T-Cell Conference"
SYBILLA co-organizes an international conference in Freiburg, Germany that focusses on gd T cell function. It takes place from 31st May to 2nd June 2012. More information can be found at: www.gammadelta-conference.de

International conference "Signaling and Gene Expression in the Immune System"
SYBILLA co-organized with SyMMyS a conference on Systems Biology, T cell activation and differentiation in Turku, Finland on the 13th and 14th August.

meeting finland 2012
Group picture at the meeting in Finland 2012.

Strategical meeting, M54
The Executive Management Committee and Governing Board meetings took place on the island Aland, Finland, from 15th to 17th August 2012.

Strategical meeting, M60
The Executive Management Committee and Governing Board meetings took place in Basel, Switzerland, from 17th to 19th January 2013. A special "modelling day" took place on the 17th January.

Strategical SYBILLA meeting, M66
The last SYBILLA meeting took place in Oxford, U.K., from the 15th to 18th September 2013. The administrative part was kept short, and instead we had several guest speakers. These were Michael Dustin (USA), Anton van der Merwe (U.K.) and Omer Dushek (U.K.).

Group picture at the meeting in Oxford 2013
Group picture at the meeting in Oxford 2013.


The 16th SYBILLA meeting
Although funding by the EU terminated in September 2013, SYBILLA members decided  to continue with their intense collaborations using other resources and to have annual meetings to further strengthen the experimental-modelling projects and to keep the friendly atmosphere. 
Thus, the next meeting takes place on the 1st and 2nd October 2014 in Madrid, organized by Balbino Alarcon !!!

The 17th SYBILLA meeting
It is planned to have the 17th SYBILLA meeting either in Turku, Finland or in  Freiburg, Germany.



 

Suggestions

merge
General comments and suggestions
should be sent to the coordinator.

(i) Suggest a new protein to include into the interactome project.

(ii) Suggestions for cooperation with SYBILLA.

(iii) Other comments.

Protocols

In SYBILLA, we have established and rigorously tested a number of standardized protocols, in order to generate accurate and reproducible data sets. 

Now at the end of SYBILLA these protocols, that have been extensively used during the projects, are made publically available. 

The following protocols can be downloaded:

xxx
xxy
yyy

Links

STS http://www.sigtrans.de/
ImmGen http://www.immgen.org/index_content.html
PubMed PubMed
iHOP iHOP
Swiss-Prot & TrEMBL Swiss-Prot & TrEMBL

Contact

Building

Scientific Coordinator

Schamel
PD Dr. Wolfgang Schamel
Dept. of Molecular Immunology
University Freiburg
Schänzlestr. 18
79104 Freiburg
Germany

Tel: +49-(0)761-203-67511
Fax: +49-(0)761-5108-423

http://www.immunbio.mpg.de

Management Partner

Carbonnelle
Dr. Sandrine Rival
Consultant NOVAMEN
69 rue de la Republique
69002 Lyon
France


Tel: +33-(0)478-924000
Fax: +33-(0)478-924001

http://www.acies.fr


Conferences

SYBILLA and the Signal Transduction Society (STS) are organizing the 15th international conference “Signal transduction – receptors, mediators and genes” to be held in Weimar, Germany, from November 07-09, 2011. This annual conference attracts approximately 250 participants and 20 industrial exhibitors each year. Researches from different disciplines including Cell Biology, Molecular Biology, Biochemistry and Immunology discuss common interests in cellular and organismic signal transduction.

 

This year’s main focus will be on Immune Cell Signaling with a special emphasis on systems biology of lymphocyte activation. A number of outstanding scientists have confirmed their participation, including Tony Hunter (USA) (who will be honored for his outstanding achievements in the field with the STS/CCS Honorary Medal 2011), Rudi Hendriks (Netherlands), Sankar Ghosh (USA), Ed Palmer (Basel), Oreste Acuto (UK), Balbino Alarcon (Spain), Wolfgang Schamel (Germany), Riitta Lahesmaa (Finland), Valeria Poli (Italy), Oliver Fakler (Germany) and Peter ten Dijke (Netherlands).

 

Thus, this world-wide unique interdisciplinary meeting will bring together leading scientists discussing the frontline of signal transduction research.

 

If you are interested in cell signaling, please register for this conference now !!!